Outlook 365 Configurations for Email Campaign Success

Does anybody have some good guidance on how best to configure Outlook 365 to support outbound email campaigns?  We are having some challenges in getting email campaigns out the door without triggering O365 shutdowns/flagging for suspicious behavior.  It seems as though our parameters within Sugar are set below (more conservative) than their recommended thresholds so it seems to be pointing to O365 configuration issues.  Any insight would be greatly appreciated.

Thanks.

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