Auto Change Email Signature based on Send From EMail Address

Hello,

Hoping someone can help - is there any way to automatically change the email signature based on the send from email address?

We have two brands in the one Sugar CRM instance, so it would be very helpful/time-saving if the email signature changed automatically based on the send-from address. I would envisage the best way would be to have a default email signature per outbound email address - similar to how Outlook signatures work.