After Upgrading CRM 11.03 to 12.00 I am Getting Error.

Dear Club Members,

I have Recently upgraded My Sugarcrm 11.03 to 12.00 it was upgraded successfully and working After 2 days Stopped working and Getting below  Errors


Wed Feb 22 07:15:02 2023 [2434][1][ALERT] Hint: ISS request failed: POST hint-interest-subscription.service.sugarcrm.com/.../createToken, headers: ["Accept: application\/json","Content-Type: application\/json","cache-control: no-cache"], body: "{\"companyId\":\"cebf9697c7ebdcf325f9f6e876358d478\",\"siteURL\":\"http:\\\/\\\/193.60.140.150\\\/sugarcrm\",\"uniqueKey\":\"r7s2fb427b3aba7521e1112315qwd70er\",\"sugarVersion\":\"12.0.0\",\"hintVersion\":\"5.4.2\"}"
Wed Feb 22 07:15:02 2023 [2434][1][ALERT] Hint: ISS response: 404,
Wed Feb 22 07:15:02 2023 [2434][1][ALERT] Hint: Problem processing event queue, error: ISS request failed: 404 -

Please help me to resolve the Error.